J. Technology and Education, Vol.26, No.2, pp.27-30 (2019)







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@Isolation of Reduced Leuco Dye and Development of Conversion Method

to Polymer




Department of Chemistry and Biology, National Institute of Technology, Fukui College

                      (Geshi, Sabae, Fukui 916-8507, Japan)


(Received July 10, 2019; Accepted August 20, 2019)



   The leuco compound formed by the reduction of methylene blue is an unstable compound that is easily oxidized. Therefore, in this study, we aimed to protect and stably isolate the reduced form of leuco and to convert the reduced form of the reactive substance to a polymer. It was possible to protect and stably isolate leucomethylene blue 1, which is a reduced form of methylene blue. In the process of converting the reactive leucomethylene blue 2 into a polymer, the product of multiple connected molecules was detected by ESI-MS measurement, as intended. However, it was confirmed that the starting material remained, and the protected leuco body was partially unprotected under the conditions of polymerization.

Keywords: methylene blue, leuco compound, dye polymer, ESI-MS