J. Technology and Education, Vol.28, No.2, pp.59-63 (2021)

研究論文

アミノ酸と相互作用するフタロシアニンの合成と配位特性

 

松井 栄樹*、加藤 岳流、渡辺 絢晴、柳田 琉偉



福井工業高等専門学校　物質工学科（〒916-8507　福井県鯖江市下司町）

*eiki@fukui-nct.ac.jp

 

Synthesis and coordination properties of phthalocyanines

that interact with amino acids

 

Eiki MATSUI*, Takeru KATO, Kensei WATANABE and Rui YANAGIDA

 

Department of Chemistry and Biology, National Institute of Technology, Fukui College

                      (Geshi, Sabae, Fukui 916-8507, Japan)

                

(Received August 27, 2021; Accepted September 26, 2021)

 

                                   Abstract

   The synthesis and characterization of new functionalized phthalocyanines (ZnPc, MgPc) with directly appended amino moieties are described. These phthalocyanine compounds (Pcs) contain external binding sites, and each of them is formed by nitrogen atoms. The synthesis of Pcs was carried out in two stages, and the formation of Pcs was confirmed by ¹³C-NMR and MALDI-MS measurement. Additionally, ESI-MS spectra of Pcs containing amino acids also indicated the formation of an amino acid–phthalocyanine complex coordinated from the outside and the metal. The design strategy of the Pcs helped to extend the development of a phthalocyanine-based cancer photodynamic therapy (PDT).

Keywords: Phthalocyanine, Binding Sites, Amino Acid Interaction, ESI-MS Spectra