J. Technology and Education , Vol.29, No.1, pp.1-5 (2022)

研究論文

極性有機分子と相互作用するポルフィリンの合成と配位特性

 

松井 栄樹*、渡辺 絢晴、谷中 佑規

 

福井工業高等専門学校　物質工学科（〒916-8507　福井県鯖江市下司町）

*eiki@fukui-nct.ac.jp

 

Synthesis and coordination properties of porphyrins

that interact with polar organic molecules

 

Eiki MATSUI,* Kensei WATANABE, and Yuki TANINAKA

 

Department of Chemistry and Biology, National Institute of Technology, Fukui College

(Geshi, Sabae, Fukui 916-8507, Japan)

 

(Received January 12, 2022; Accepted February 14, 2022)

 

Abstract

   The synthesis and characterization of a new functionalized porphyrin (Mg8OHPor) with eight directly appended phenolic hydroxyl groups are described. The synthesis of this porphyrin was carried out in three stages: first synthesizing H₂8OMePor, then converting it to H₂8OHPor, and finally complex formation into Mg8OHPor. The formation of porphyrins was confirmed by ¹³C-NMR and ESI-MS measurement. Additionally, ESI-MS spectra of Mg8OHPor containing polar organic molecules also indicated the formation of an organic molecule–porphyrin complex coordinated from the phenolic hydroxyl groups and the metal. The design strategy of the porphyrin helped to extend the development of a porphyrin-based cancer photodynamic therapy (PDT).

Keywords: Porphyrin, Phenolic Hydroxyl Groups, Polar Organic Molecule, ESI-MS Spectra