糖鎖を有する水溶性フタロシアニンの合成と親水性の評価

The synthesis and characterization of new functionalized phthalocyanines bearing directly appended sugar chains are described. These phthalocyanine derivatives (Pcs) possess four sugar chains and were synthesized via a three-stage process using sugar-substituted dicyano derivatives obtained through a substitution reaction. The formation of the Pcs was confirmed by negative-mode MALDI?MS and UV?Vis measurements, which clearly revealed the Soret and Q bands of the phthalocyanine skeleton. This design strategy contributes to the development of novel phthalocyanine-based agents for cancer photodynamic therapy (PDT).