J. Technology and Education, Vol.19, No.2, pp.51-61, 2012

研究論文

Salacia reticulataのマウス接触皮膚炎抑制作用

 

芳野 恭士*¹、宮本 潤基¹、間部 涼祐¹、近藤 郁美子¹、善養寺 優香¹、

金高　隆²、古賀 邦正³

¹沼津工業高等専門学校　物質工学科（〒410-8501　沼津市大岡3600）

²株式会社盛光（〒411-0931　静岡県駿東郡長泉町東野50-6）

³東海大学　開発工学部（〒410-0395　沼津市西野317）

*k-yoshino@numazu-ct.ac.jp

 

Preventive Effects of Salacia reticulata on Mouse Contact Dermatitis

 

Kyoji YOSHINO, Junki MIYAMOTO, Ryosuke MANABE, Fumiko KONDO,

Yuka ZEN-YOJI, Takashi KANETAKA, Kunimasa KOGA

¹Numazu College of Technology (3600 Ooka, Numazu, Shizuoka 410-8501, Japan)

² Seiko Co., Ltd (50-6 Higashino, Nagaizumi, Shizuoka 411-0931, Japan)

³ Tokai University (317 Nishino, Numazu, Shizuoka 410-0395, Japan)

 

(Received July 3, 2012; Accepted July 31, 2012)

 

Abstract

In this study, the preventive effects of water extracts prepared from the leaves and stems of Salacia reticulata on mouse contact dermatitis were investigated. The oral administration of the extracts of S. reticulata to mice at doses of 200 and 400 mg/kg body weight significantly inhibited mouse contact dermatitis. The increases of the levels of some cytokines, such as interleukin-12 and g-interferon, in sera and ears of mice with contact dermatitis were suppressed by the oral administration of these extracts of S. reticulata. The percutaneous administration of these extracts at doses of 0.2 mg/ear also affected the preventive effects on mouse contact dermatitis. Some polyphenolic components, such as mangiferin, (-)-epigallocatechin, and (-)-epicatechin, inhibited mouse contact dermatitis and these compounds may have contributed to the effects of the extracts prepared from the leaves and stems of Salacia reticulata.

Key words: Salacia reticulata, Mouse, Contact dermatitis, Polyphenols