J. Technology and Education, Vol.21, No.2, pp.45-51 (2014)

研究論文

サラシア（Salacia reticulata）のマウス耳介皮膚における抗炎症作用

 

芳野恭士*¹、近藤郁美子¹、金高　隆²、古賀邦正³

¹沼津工業高等専門学校　物質工学科（〒410-8501　沼津市大岡3600）

²株式会社盛光（〒411-0931　静岡県駿東郡長泉町東野50-6）

³東海大学　開発工学部（〒410-0395　沼津市西野317）

*k-yoshino@numazu-ct.ac.jp

 

Anti-inflammatory Effect of Salacia reticulata on Mouse Ear Skin

 

Kyoji YOSHINO, Fumiko KONDOH, Takashi KANETAKA, Kunimasa KOGA

¹Numazu College of Technology (3600 Ooka, Numazu, Shizuoka 410-8501, Japan)

² Seiko Co., Ltd (50-6 Higashino, Nagaizumi, Shizuoka 411-0931, Japan)

³ Tokai University (317 Nishino, Numazu, Shizuoka 410-0395, Japan)

 

(Received May 23, 2014; Accepted July 8, 2014)

Abstract

In this study, the inhibitory effects of water extracts prepared from the leaves and stems of Salacia reticulata on dermatitis were investigated by using a simple dermatitis model of arachidonic acid-induced mouse ear edema. Percutaneous administration of the extracts of leaves and stems at a dose of 0.2 mg/ear prevented the inflammation of mouse ear skin. Phenolic components in these extracts, mangiferin, (-)-epicatechin, and (-)-epigallocatechin, tended to inhibit mouse ear edema. Some antioxidants, iron chelators, lipoxygenase inhibitors, cyclooxygenase inhibitors, superoxide anion radical scavengers, and/or polyphenols having these functions also prevented mouse ear edema. Therefore, the phenolic components could contribute to the effects of the extracts prepared from the leaves and stems of S. reticulata. These results suggest that water extracts prepared from S. reticulata are natural components of cosmetics that are effective for preventing skin inflammation.

Keywords: Salacia reticulata, Skin inflammation, Mouse, Antioxidant