J. Technology and Education, Vol.25, No.2, pp.47-55 (2018)



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Preventive Effect of Salacia reticulata on Formation of Melanin


Kyoji YOSHINO1, Genki KOSEKI1, Momo Suzuki1, Yuka ZEN-YOJI1,

Ayaka YOSHINO1, Kunimasa KOGA2, Takashi KANETAKA3

1National Institute of Technology, Numazu College (3600 Ooka, Numazu, Shizuoka 410-8501, Japan)

2Tokai University (317 Nishino, Numazu, Shizuoka 410-0395, Japan)

3Seiko Co., Ltd (50-6 Higashino, Nagaizumi, Shizuoka 411-0931, Japan)


(Received September 14, 2018; Accepted October 26, 2018)



The inhibitory effects of a Salacia plant, Salacia reticulata, on the production of melanin in the skin were investigated using in vitro and in vivo evaluation systems. Aqueous extracts prepared from the leaves and stems of S. reticulata inhibited the activities of tyrosinase in vitro, and the actions were stronger than that of the extract of rosemary (Rosmarinus officinalis). The inhibitory effect of Salacia leaf and stem extracts on tyrosinase activity would be of an uncompetitive type. Several known polyphenolic components in Salacia leaf and stem extracts could not contribute sufficiently to their actions. In in vivo study, the ingestion of solutions of Salacia leaf and stem extracts and/or administration of the ointment including Salacia leaf extract to mice irradiated with ultraviolet B (UVB) tended to suppress elevations of melanin-like pigments and oxidative stress in their skin tissues. These results suggest that Salacia leaf and stem extracts are expected to suppress brownish pigmentation of the skin due to increased melanin pigment.

Keywords: Salacia reticulata, Melanin, Tyrosinase, Mouse, Skin, Oxidative stress