J. Technology and Education, Vol.25, No.2, pp.47-55 (2018)

研究論文

 

サラシア属植物（Salacia reticulata）のメラニン形成抑制作用

 

芳野恭士*¹、小關元気¹、鈴木 百¹、善養寺優香¹、芳野文香¹、古賀邦正²、金�� 隆³

¹沼津工業高等専門学校　物質工学科（〒410-8501　沼津市大岡3600）

²東海大学 開発工学部（〒410-0395 沼津市西野317）

³株式会社盛光（〒411-0931 静岡県駿東郡長泉町東野50-6）

*k-yoshino@numazu-ct.ac.jp

 

Preventive Effect of Salacia reticulata on Formation of Melanin

 

Kyoji YOSHINO¹, Genki KOSEKI¹, Momo Suzuki¹, Yuka ZEN-YOJI¹,

Ayaka YOSHINO¹, Kunimasa KOGA², Takashi KANETAKA³

¹National Institute of Technology, Numazu College (3600 Ooka, Numazu, Shizuoka 410-8501, Japan)

²Tokai University (317 Nishino, Numazu, Shizuoka 410-0395, Japan)

³Seiko Co., Ltd (50-6 Higashino, Nagaizumi, Shizuoka 411-0931, Japan)

 

(Received September 14, 2018; Accepted October 26, 2018)

 

Abstract

The inhibitory effects of a Salacia plant, Salacia reticulata, on the production of melanin in the skin were investigated using in vitro and in vivo evaluation systems. Aqueous extracts prepared from the leaves and stems of S. reticulata inhibited the activities of tyrosinase in vitro, and the actions were stronger than that of the extract of rosemary (Rosmarinus officinalis). The inhibitory effect of Salacia leaf and stem extracts on tyrosinase activity would be of an uncompetitive type. Several known polyphenolic components in Salacia leaf and stem extracts could not contribute sufficiently to their actions. In in vivo study, the ingestion of solutions of Salacia leaf and stem extracts and/or administration of the ointment including Salacia leaf extract to mice irradiated with ultraviolet B (UVB) tended to suppress elevations of melanin-like pigments and oxidative stress in their skin tissues. These results suggest that Salacia leaf and stem extracts are expected to suppress brownish pigmentation of the skin due to increased melanin pigment.

Keywords: Salacia reticulata, Melanin, Tyrosinase, Mouse, Skin, Oxidative stress