J. Technology and Education , Vol.28, No.1, pp.1-4 (2021)








Synthesis of phthalocyanine compounds with heterocyclic condensation


Eiki MATSUI* and Akari HATTA

Department of Chemistry and Biology, National Institute of Technology, Fukui College

(Geshi, Sabae, Fukui 916-8507, Japan)


(Received March 26, 2021; Accepted April 16, 2021)



   The synthesis and characterization of new functionalized phthalocyanines directly condensed with heterocyclic moieties are described. These phthalocyanine compounds (Pcs) formed from planar heterocycles contain four extra metal binding sites, and one of them is formed by five nitrogens. Synthesis of Pc was carried out in two stages, and the formation of Pc was confirmed by 1H-NMR, HMQC, UV-vis absorption spectrum, and MALDI-MS measurement. The design strategy and optical properties of Pcs help to extend the development of phthalocyanine-based cancer photodynamic therapy (PDT).

Keywords: Phthalocyanine, Heterocyclic Condensation, Binding Sites, Metal Ion Binding